Glutathione Reductase (GR): Glutathione Reductase is an enzyme that plays a crucial role in the glutathione cycle and the cellular antioxidant defense system. It is responsible for converting oxidized glutathione (GSSG) back to its reduced and active form (GSH). This process is essential for maintaining cellular redox balance and protecting cells from oxidative damage caused by reactive oxygen species (ROS). GR is widely distributed in various tissues and organisms and is critical for maintaining cellular health and integrity.
Glucocorticoid Receptor (GR): The Glucocorticoid Receptor (GR) is a type of nuclear hormone receptor that binds to glucocorticoid hormones, such as cortisol. It plays a key role in mediating the physiological effects of glucocorticoids, which are steroid hormones involved in regulating a wide range of processes in the body. When glucocorticoid hormones bind to the GR, the receptor becomes activated and translocates to the cell nucleus. Once there, it modulates the expression of specific target genes, affecting various cellular functions, including metabolism, immune response, and stress regulation.
