I'm not sure what you mean by upgraded. If you mean with all components except methane removed, dual fuel diesel engines can have injector nozzle overheating problems. Biogas which still contains H2S produced acid gases on combustion, which cause a number of difficulties. Biogas which still contains its CO2 will not sustain combustion alone in a Diesel engine. The first and last of these problems can be solved by using a proportion of Diesel fuel.Solutions to the second are well-established.
All of the potential problems are soluble, and if properly maintained, duel fuel diesel engines running on biogas should have no unusual operational problems- see:
Tippayawong, N., A. Promwungkwa, and P. Rerkkriangkrai. "Durability of a small agricultural engine on biogas/diesel dual fuel operation." Iran J Sci Technol Trans B Eng 34.B2 (2010): 167e77.
Sean, upgraded means biogas is treated through a series of process to improve CH4 content and greatly reduce CO2, H2S, moisture and other impurities. Upgraded biogas quality is similar to natural gas (i.e, CH4 95% or more, CO2 is less than 1%) which can be injected into the natural gas pipeline or used as a vehicle fuel
As per my research Experience there is no such issue of change in engine operation or on maintenance part. Specifically saying it totally depends upon upto what extent you are scrubbing the biogas (Removal of H2S , CO2 and moisture) and Compress it to approx 200 bars.I has gone through researchers performing several trials on automotive engine using upgraded biogas/biomethane instead of CNG.