Some studies reveal that SARS-CoV-2 virus activity can be mitigated at the alkaline pH medium (above pH= 7.5). Any explanation about the mechanism or the Chemistry behind this phenomenon.
SARS-1 has a trypsin cleavage site and SARS-2 has a furin cleavage site at the S1/S2 spike protein junction, these enzymes are ph dependent and furin has reduced activity at high ph levels, this is one reason as to why inhibition can happen as furin is used for viral genome entry into the cell.