Assay for Resistance in Drug Development?

Hello Everyone, We are attempting to develop a targeted therapy drug and would like to know what the likelihood is of the targeted molecule gaining resistance against our drug. Is there any assay...

30 August 2016 7,657 3 View

While preparing agarose gels why is ethidium bromide added?

Can it be replaced by any other reagents?

24 August 2014 2,849 17 View

How to perform Kaplan-meier survival analysis in SPSS?

Hi everyone, This is my first time of attempting to run survival analysis. I have a data on patients with End-stage Kidney Diseases (ESKD). I would want to run survival probability by treatment...

16 February 2021 2,647 3 View

CT image preprocessing in python?

I have a 3D CT image of a car engine in raw form with no header information. When loaded into numpy array as 16 bit unsigned integer, I noticed that the values range between 0 to 52000. Is this...

15 February 2021 4,736 3 View

Patients with chronic kidney disease could get COVID-19 vaccine?

04 February 2021 278 4 View

Need a research paper for multi speaker and single microphone acoustic echo cancellation?

Hi, I am working on a problem that involves multiple smartphones/tablets. All devices are playing the same sound with synchronization difference up to +- 5ms. Now, there is an echo issue and I...

02 February 2021 5,929 3 View

PME calculation on a GPU GROMACS?

Hi all I used the following script to run the simulation but for some reason, I was not able to assign GPU to do the PME calculation? How to do that? The size of the system is huge (600.000...

14 January 2021 7,441 1 View

Micro CT of fiber reinforced composite - phase identification?

Hi, I have a fiber reinforced polymer matrix composite and I am analyzing it by micro CT but I am unable to reconstruct the fiber phase of the composite. how can I find a solution for this?...

07 January 2021 5,680 1 View

What are the Methods to evaluate nephroprotective activity of herb in diabetic and hypeetensive nephropathy or CKD?

Usualy nephroprotective drugs of plants orgin were evaluted in nephrotoxicity animal model. But CKD secondary to HTN and DM is also common. What are the method to develop these animal model in a...

28 December 2020 161 2 View

How can i save multi medical images after some preprocessing in a file ?

i have multi x ray images after preprocessing on it , i saved them as a vector in file .dat but this file not accepted in next stage (convolution neural network ). how can i save all image in...

27 December 2020 1,369 4 View

What is the best Quality of Life questionnaire for chronic patients?

Hello! I am looking for a SHORT questionnaire/scale to measure Quality of Life in chronic patients (e.g. fibromyalgia, or multiple sclerosis). Ideally, validated for English and Spanish speakers....

22 December 2020 9,962 4 View

Acceptable Beta Values for Unstandardized Coefficients in Multi Regression Analysis?

I want to confirm that, is there any specific acceptance criteria for beta values as well under Unstandardized Coefficients panel of Coefficients table in Regression analysis. Because I am getting...

18 December 2020 810 3 View