Any advice on the synthesis of "Acetylenedicarboxylic acid" from "but-2-yne-1,4-diol"?

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Marcel Kienle

Hi Viktor,

if your are only interested in the product, use the standard procedure for the synthesis of acetylenedicarboxylic acid:

1) bromination of maleic acid

2) dehydrohalogenation of dibromosuccinic acid with KOH

Best regards,

Marcel

Adel Amer

Zvarych,

Try CrO3/acetone procedure. See

--- Heilbron, Ian et al Journal of the Chemical Society, 604-7; 1949

Good luck

Richard Bryan

You should take care in handling both the diol and the diacid, they are both serious skin irritants and can cause very bad skin problems with some people. I would just buy it , it is not expensive

Madhukar Baburao Deshmukh

Oxidation of 2-butyne 1,4-diol by CrO3 in acid gives but-2-yne dioic acid.