anti-osteoarthritis effect of the turmeric is related to curcumin concentration in the extraction. Bioavailability of the curcumin. This show a poor absorption in GI. So anti-osteoarthritis effect of curcumin is related to the purity of the drug and the type of the formulation. 

Hello Adriana,

the equivalent to a 500mg Curcumin capsule (95%) is 25 g rhizoma.

Do you want to test it, for example, as Curcuma powder (spice) which is the milled rhizoma?

I suggest here to add 100mg black peper for better bioavailability.

There are also 500mg curcumin capsules on the market where 8 mg bioperin is added which is black pepper extract.

Curcumin is able to replace pain meds without side effects to the stomach.

I consider Curcumin as better COX-2 inhibitor.

On the other hand you have to avoid the tyramin trap. Patients should not eat

Sauerkraut, old cheese etc. containing tyramine from fermentation otherwise blood pressure may sky rock.

The good side is that inflammatory cytokines are reduced like IL-1 beta and IL-6,

for example.

The bad side is that Curcumin cannot cure arthritis.

Therefore I tested a combination with boswellia serrata (3 x 400mg daily)

and Curcumin (as needed dependent on pain level).

Bowellia acids act as a cathepsin G inhibitor and arthritis signs like

Heberden nodes on the fingers are removed within 8 weeks.

The total time of intake needed is 3 month. The observation here is that arthritis

will not come back. On the other hand if patients stop intake after 2 month because there is no pain arthritis will come back later in life.

Here is some research about the mechanisms of boswellia acids as pdf file:

https://www.uni-muenster.de/imperia/md/content/pharmaz_und_med_chemie/forschen/arbeitsgruppen/agverspohl/werz_weihrauch091110.pdf

Regards

Hugo

Dear Hugo, thank you very much for your interesting answer e for link

. Have a good day Adriana