Is bryostatin-1 a cytotoxic agent or rather an agent belonging to the targeted therapy area?

Dear Colleagues, I am searching high-impacted scientific journals giving a "crystal-clear" response to my question here above, but as yet unsuccessfully. If anyone has such articles, I would be...

07 August 2016 9,357 4 View

Does it exist ADVANCED STAGE cancers without identified genomic mutations?

02 March 2016 9,860 16 View

How the MDR phenotype is switching on in cancer cells? It seems that this question raises more than weak interest ...

Among the unfortunately (too) large set of chemoresistance mechanisms in cancer cells is the so "popular" ABC-related pump / MDR phenotype. While there are hundreds (if not housands) of articles...

02 March 2016 9,564 13 View

Clinical Phase II to Phase III failures in oncology?

I am requesting the help of the RG community to provide me with recent (no older than 5 years) articles (from very high and only from very high ranked journals) clearly 1) indicating how many...

01 February 2016 591 20 View

Cancer cell cannibalism?

Would be "some RG Community members" so kind in providing me with articles (even if not top-ranged) about any type of chemicals able to induce ENTOSIS SPECIFICALLY in CANCER CELLS.Thank you very...

01 February 2016 8,066 4 View

Entomogenous fungi and human cancers?

Tank you for every one who actually helped me! I will cite them in the review I am currently writing with colleagues on this subject. Best regards Robert

31 December 2015 1,519 2 View

Mediation path analysis - Can I run two seperate models?

I am wanting to run a serial mediation model with 2 x IVs, 2 x MVs, and 3 DPs (all continuous). Is it problematic to run 2 different models for each IV, keeping the MVs and DPs the same in each...

27 February 2021 5,681 3 View

Physical-chemical formation of stalactites/stalagmites. what promotes the formation/growth of these structures?

I know, or think I do, the basic idea behind these natural structures, as from what I know they form due to water dripping from the top leaving a salt deposit behind. But started to wonder about...

22 February 2021 1,400 4 View

Is there a suitable way to confine cell attachment area inside a multi-well plate?

Are there any types of cylindrical cell culture inserts that are designed to confine cell seeding area? Say, if I'm using a 12 well plate (3.5 cm^2/well), but only want to seed cells in the middle...

22 February 2021 7,127 4 View

How can a reference point be fixed to an attachment point in Abaqus?

I am currently trying to copy an assembly feature, that is present in an old version of the model I am using, onto a new model. The feature is a reference point that is fixed to an attachment...

16 February 2021 8,872 2 View

Which Journals would you advise to submit a Letter which briefly talks about neurosurgical treatment of neuro-oncological patient during Sars-COV-2?

Possibily not an open access journal which does not add any publishing costs once being accepted. Thank you in advance

09 February 2021 717 6 View

How to determine the significance of "diagonal" contrasts in two-way ANOVA interactions on SPSS?

Hi all, I'm running a 2 x 2 between-subjects ANOVA with the setup in the attached image (kindly refer to JPG attachment). I understand that calculating simple effects involves determining...

09 February 2021 547 3 View

Student writing his own Learning Outcomes - is this the way forward?

'Students just dont want to study; they are here to waste time!' I have heard this phrase many times; so are the students solely to be blamed? We will find many students who just dont seem to...

04 February 2021 8,546 22 View

Whether L version and D version peptidesshould have identical NMR, especially in the state of self-assembly?

Whether L version and D version peptides should have identical NMR, especially in the state of self-assembly have to have identical NMR? How to use HRMS to confirm L version or D version...

01 February 2021 6,756 4 View

How to interpret multiple bell shaped curves in Kratky plot?

Hi, I'm trying to analyze a Kratky plot generated from my SAXS data. I am seeing multiple bell-shaped curves in my Kratky plot and I am not able to find any source to get relevant info on this...

20 January 2021 2,474 1 View

Can you suggest literature studying the conditions information and evidence can influence manager decisions in social impact sectors?

I am working on improving the use of digital innovations at scale globally. Most of the innovations I work with provide relevant knowledge on improving the performance of projects, programs, and...

16 January 2021 1,120 5 View