Hello optogenetics community,

I am currently performing optogenetic surgeries that require me to secure optic fiber implants in place over a nucleus of interest in the mouse brain. I typically secure the implants in place using layers of Metabond, which works very well (dries quickly, minimal removing of implants). However, I understand that Metabond is effective because it actually penetrates the surface it is adhering to. Fibre optics don't work if the cladding surrounding the core is damaged. Typically in my surgeries there is a little bit of fibre exposed between the ferrule and the skull, and this get's covered with Metabond. Has anyone observed a decrease in fibre implant output if it comes in contact with Metabond?