I am doing alkylation at the 1st position of benzimidazole nucleus. At the second position there is an amide group. I am trying with pot. carbonate + DMF. The alkylating agent is 3-bromo propan-1-ol. In the reaction it is not happening. Can anybody suggest the TLC spot of this product with reference to reactant amine?
Ahmed K.H. Kadhim
you can alkylation 1st position by using KOH then added 3-bromo propan-1-ol.
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Kalleda Srinivasa Rao
Take benzimidazole, heated to 100 oC, add 3-bromo propan-1-ol and the mixture was heated to 150 oC for 48hrs, (Neat reaction ) Check TLC. I hope this method should work , if you send your reaction details i can help more.
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