When I was reading about quorum sensing mechanism, it seems to be that they are bacteriostatic. But, their are reports which are saying that QS agents can act as an antibacterial.
Can anybody suggest me the answer?
Since quorum sensing is not essential for bacterial replication and survival under the type of laboratory growth conditions in which MICs are measured, I would say that inhibitors of quorum sensing are, in general, neither bacteriostatic nor bactericidal. They may reduce virulence in vivo, however.
Thanks for the answer Adam Sir,
But sir now a days people have started using this strategy, for targeting bacterias.
There may well be a place in clinical medicine for agents targeting bacterial virulence factors and quorum sensing, such as in prevention and treatment of biofilms and chronic infections. In acute care of immediately life-threatening infections, however, bactericidal drugs are most desirable, since any delay in destroying the infectious agent increases morbidity and mortality, lengthens the hospital stay, and increases treatment cost.
According to me the potential quorum sensing inhibitor must be bacteriostatic. Because most of the QS inhibitors reported so far, were determined for their anti-qs activity only at their sub-MIC level (Sub-lethal dose). I agree with David that the term antibacterial broadly refers to both bactericidal and bacteriostatic. The quorum sensing inhibitors should regulated the bacterial phenotypes without affecting the bacterial growth pattern. So, the QS inhibitor should be bacteriostatic.
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