I observed an interesting pattern that resembles a "flattening" of the near-UV region of the absorbance spectrum of the rat intestinal mucus in the streptozotocin-induced model of sporadic Alzheimer's disease. I'm studying qualitative and quantitative alterations in mucus as there seem to be some changes in the gut-brain axis, intestinal redox homeostasis, and cell turnover (Article Failure of the Brain Glucagon-Like Peptide-1-Mediated Contro...
,Article Disbalance of the Duodenal Epithelial Cell Turnover and Apop...
). I observed a quite dramatic change in the number and responsiveness of goblet cells so the observed spectral shift may be driven by a component of mucus. Another possibility may be a component of bile, a peptide or bilirubin/biliverdin, or even complexation between bilirubin/biliverdin and some other molecule (e.g. I found a similar pattern in a publication by Klinke et al. who reported flattening of the biliverdin near-UV spectrum upon binding to bacteriophytochrome?Article Crystallization and preliminary X-ray characterization of th...
). Any ideas about what I may be looking at?Thanks!
The report of UV-visible wavelength range in quantitative tissue spectroscopy has increased over last few years. The optical spectroscopy findings quantitatively in the UV-wavelength region might be a focus not only for study of malignancy but also other ailments too. I do suggest to go through the publication- Quincy Brown J, et al. Curr Opin Biotechnol 2009; 20:119-1311.
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