Will a lack of nutrient cause fibrosis of a chondrocyte? Can the change of culture medium osmotic pressure result in chondrocyte fibrosis?

This picture is taken after a one-week culture in droplet. Why do the chondrocytes become like this? I guess maybe it's due to a lack of nutrients or the change of osmotic pressure. What do you...

04 September 2014 4,064 5 View