Why losing LCMS/MS sensitivity for Human PTH(1-34) when I conjugate Alendronate with PTH(1-34) ?

I have an LCMS/MS assay to detect human parathyroid hormone (PTH 1-34) in the plasma going. My LOD for PTH(1-34) is as low as 500 pg/mL. But when I conjugate the human parathyroid hormone...

09 September 2017 5,405 6 View