Ugur Bozuyuk

4 Questions 7 Answers 0 Followers

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Dispersion of pDNA loaded nanoparticles?

Dear all, I encapsulate pDNA into my nanoparticles, however, my particles are extremely sensitive to pH changes. For radical pH changes like from 4 to 7.4, they aggregate quickly. It cannot be...

22 November 2017 6,929 2 View

pH of the reaction of acid anhydrides with amine groups to form amide bonds?

Dear all, I am trying to conjugate amino groups of chitosan with methacrylic anhydride. I am trying to understand chemistry of the reaction. Here is the...

06 July 2017 1,866 10 View

Reaction medium of NHS - Amine reaction?

Hi everyone, I am trying to conjugate primary amine of chitosan with NHS-PEG-MAL. Chitosan is in a solution. In literature, some people directly add NHS-PEG-MAL powder to chitosan solution while...

28 March 2017 8,061 4 View

How does a linear polymer dissolve in a solution and What do I see in DLS?

Hi everyone, I have deacetalyzed low molecular weight chitosan polymer which is soluble in %0.5 (v/v) acetic acid solution. I prepared chitosan/acetic acid solution (0.5 mg/mL) and used DLS to see...

18 October 2016 730 11 View