Sonali Sengupta

5 Questions 15 Answers 0 Followers

Questions related from Sonali Sengupta

Is the CD4+ T cell line SupT1 good for invitro Th differentiation studies such as for cytokine expression ?

I want to study differentiation of CD4+ T cells in vitro into cytokine secreting Th1/Th2 subset. Is there a good protocol for this ? Is the CD4+ SupT1 cell line good for this study ? Thank You.

16 September 2018 2,496 3 View

Will cancer therapy eventually involve targeting tumor suppressors/oncogenes and the tumor microenvironment simultaneously ?

Activating a tumor suppressor/inhibiting an oncogene within a tumor by a drug may alter tumor cellular state. Tumor cells may adapt and give survival cues to the tumor microenvironment. So drug...

14 January 2018 4,265 8 View

Can the oncogenic or tumor suppressor function change with cellular context? Would this have implications for cancer biology/therapy ?

For example if an oncogene is within a cell that lacks components of the downstream signaling pathway, then it will not function as an oncogene anymore. Could this be the reason that oncogenes...

02 January 2018 9,145 12 View

Is biology of primary tumor opposite to/different from epithelial-mesenchymal transition biology ?

Note: EMT (epithelial mesenchymal transition) and MET (mesenchymal epithelial transition) are opposing processes .Therefore should have theoretically opposite biologies.

22 August 2017 7,199 3 View

Honokiol-Mechanism and downstream activation

Does the plant derived polyphenol (Honokiol) function through the epigenetic regulator Tri-thorax group of proteins ?

01 January 1970 8,504 0 View