Ritesh Raval

5 Questions 5 Answers 0 Followers

Questions related from Ritesh Raval

What is the most appropriate statistical analysis for a multiple dose phase 2 weight loss study ?

There is a phase 2 trial of a novel weight loss drug, comprising a 50mg dose, 100mg dose and placebo, with n=30 for each group. The primary endpoint is absolute weight loss at 3 months. I am new...

03 March 2016 8,958 2 View

How can I assess binding selectivity of a drug to a gene?

hi i wanted to ask, if i am developing a novel drug that targets a gene expressing a signalling protein in the mid brain, how can i test to establish how selective the drug is to binding to the...

10 October 2015 9,514 3 View

Investigating the mechansims underlying decreases in blood pressure in an animal model with treatment using a soluble epoxide hydrolase inhibitior?

Inhibitors of soluble epoxide hydrolase cause decreases in blood pressure as inhibition of the enzymes leads to increases in concentrations of epoxyeicosatrienoic acids. These lower blood pressure...

04 April 2014 2,218 1 View

Why is the crystal structure of TGR5 difficult to produce?

I have been reading up on the TGR5 receptor and how it could be used in treatment of various aspects of metabolic syndrome, however, a crystal structure has not yet been found and through my...

11 November 2013 9,173 3 View

Possible future work of an investigation to test for leaky scanning?

We did an investigation to see if translation was initiating at another ATG start codon due to leaky scanning. We constructed a plasmid expression vector and a restriction digest to confirm the...

04 April 2013 10,039 4 View