Quoc-Viet Le

4 Questions 4 Answers 0 Followers

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How can I set up in vivo human tumor xenografted mouse model for PD1/PD-L1 blockade therapy?

I am going to try the new PD-L1 inhibitor in vivo experiment.However, when I screened the several murine cancer cell lines in my lab, there is no cell line expressing PD-L1. If I want to use human...

24 October 2016 4,822 2 View

What are difference between ex vivo isolated dendritic cell (DC) and in vitro dendritic cell?

I am working on antigen vaccine delivery system targeting dendritic cell. When I refer some paper to search the dendritic cell (DC)model for in vitro targeting efficacy test of my vaccine delivery...

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Can DMSO dissolve all kind of peptide ?

My peptide sequence is FFFFFFFFEEEE (F8E4). I read some guidelines for peptide handling and I firgue out DMSO is most suitable solvent for hydrophobic peptide. I try to dissolve 10 mg peptide in...

22 January 2016 7,245 8 View

Replace the L-ribose nucleotide with D-ribose nucleotide of aptamer?

I am thinking about using anti-CXCL12 aptamer (NOX-A12) as targeting moeity in drug delivery system. This RNA aptamer has structural configuration of unnatural L-ribose nucleotides. If I use the...

21 July 2015 8,930 1 View