Philippa Wells

2 Questions 5 Answers 0 Followers

Questions related from Philippa Wells

For a polygenic risk score using GWAS summary stats as the base data set, and raw genotype data as the target, what SNP P value cut off should I use?

I need to choose a P value cut off for SNPs. Ususally, I would be able to determine the optimal P value cut off by regressing the resultant scores from running the PRS at various thresholds onto...

19 September 2017 2,751 6 View

Is between study heterogeneity the only consideration in choosing fixed or random effects models of meta-regression?

I am undertaking a meta-analysis of cognitive impairment in opiate addiction as shown by neuropshychological testing. I am looking for clarification as to which model of meta-regression is the...

07 June 2016 5,470 5 View