P. Manchandani

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Questions related from P. Manchandani

What is highest tolerable dose of colchicine that can be given intraperitoneally for the internalization of renal megalin in Sprague Dawley® rats?

The aim is to study the effect of colchicine on the re-distribution and internalization of megalin (lrp2) protein. The literature study suggest that 5mg/kg is the highest dose tolerated dose given...

10 February 2015 8,074 1 View

Precipitation of protein in rat organ homogenate?

I am trying to establish an LC-MS/MS assay of my drug in SD rat organ homogenate. 5% TCA was used for protein precipitation. The assay was linear with good LLOQ for lungs and kidneys. However for...

27 June 2014 9,613 0 View