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In the case of oral film, if hydrophilic drug that is not lipid soluble, is used as API, how does it cross the oral mucosal barrier to reach the bloodstream?
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HPMC has good film forming properties and other characteristics which are suitable for developing ODF. But are there any limitations ar drawbacks of using HPMC in ODF?
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For in-vitro drug release of orally disintegrating film made of HPMC & gum acacia, cumulative drug release was found more than 100%.
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