Mohit Tripathi

4 Questions 16 Answers 0 Followers

Questions related from Mohit Tripathi

How to experimentally determine optical purity/ee of an organic compound?

What are the best methods to determine the optical purity of any organic compound (synthesised or naturally isolated)? If the sp. rotations of the enantiomers is known in literature, then by...

01 February 2015 8,000 13 View

How to interpret -NH and -OH peaks in proton NMR and how to report them in a publication?

We all know that peaks due to -NH or -OH can come anywhere in the proton NMR spectrum. Sometimes they may also be absent. My query is regarding how to interpret and report these in publications....

07 November 2014 6,053 22 View

Which is the best and cheapest method for enantioselective aldol-type reactions?

I need to react an aromatic aldehyde with an active methylene (flagged by an ester and an ether group). Chiral auxillaries are very expensive. Methods based on proline as a catalyst are reported,...

03 October 2014 2,660 2 View

I have to protect 4-5 phenolic groups. Finally, need to deprotect them (need mild conditions) without racemization. Any Suggestions? I tried TBS, THP.

During total synthesis of a natural product, I am facing problem during final step where I need to de-protect around 4 phenolic protections. I tried TBS but it did not last till the final steps....

01 October 2014 8,181 8 View