Mohammadkazem Khoeeniha

4 Questions 2 Answers 0 Followers

Questions related from Mohammadkazem Khoeeniha

Why does drug release decrease from the coat of fixed dose combination?

I am developing a Fixed Dose Combination dosage form, which have an active pharmaceutical ingredient in the coat and another one in an extended release core of tablet. During development, I have...

18 December 2020 3,469 2 View

Molecules which have two carboxylic acid as buffering agent

We often have molecules like Methotrexate which has two carboxylic groups. These two similar substitution have different pKa. So, the ionization pH of each one is different. Also, they are weak...

01 January 1970 9,598 3 View

Visual inspection of dark color parenteral solution

How should visual inspection be done for parenteral solution with dark blue color in transparent vial? We are manufacturing a new parenteral product which has dark blue color and is filling in...

01 January 1970 509 3 View

Turbidity of re constituted lyophilized drug

Unstable drug in aqueous solution is drying by lyophilization process to produce dry cake which makes solution after reconstitution by suitable diluent before administration for patients. In drug...

01 January 1970 2,033 0 View