Leonard Amaral

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Questions related from Leonard Amaral

Citations descending and ascending order by RG?

It seems to me that it would be extremely useful for the RG members to be able to have their citations by descending and ascending order much like Scopus. Companies can use this added criterion...

02 February 2018 2,662 0 View

Should the identity of the reviewer be made in the title page of the publication?

Reviewers perform an important role that results in the improved quality of a publication. However, with the exception of a few proceedings and books, they are not identified in the peer reviewed...

07 July 2013 3,367 42 View

Will nano antibodies directed against exposed TolC antigens of the RND efflux pump system inhibit efflux pump activity responsible for mdr phenotypes?

RND efflux pumps of Gram-negative bacteria bestow an MDR phenotype. Because deletion of the AcrAB-TolC main efflux pump of E. coli promotes the over-expression of the AcrEF-TolC as well as 8...

06 June 2013 7,325 0 View

Are efflux pumps of bacteria the means by which all secretions from the bacterium take place?

The first response of bacteria to a noxious agent such as an antibiotic is the induced over expression of efflux pumps. Once the threat of the noxious agent passes, the level of efflux pump...

06 June 2013 9,210 5 View

Besides novobiocin and chlorpromazine, are there other compounds that cure bacteria of plasmids?

A specific concentration of chlorpromazine eliminates plasmids from bacteria as a consequence of inhibiting plasmid replication whereas replication of the bacterial genome is unaffected. The...

05 May 2013 1,001 2 View

Are there any cancer cell lines that express more than one efflux pump responsible for the MDR phenotype of the cell?

Normal cells human cell types express different ABC transporters that when over expressed in the cancer cell render the cancer cell with an MDR phenotype. However, the genome of the normal cell...

05 May 2013 1,482 8 View

Can specific lasers matched to the energy level of a molecule create new molecules not readily made by conventional organic chemistry methods?

We have exposed a number of bioactive pure compounds to lasers of a given nm wavelength and energy level for varying periods of time, followed the result of exposure via thin layer chromatography,...

05 May 2013 6,668 1 View

Should doctoral students of biomedical areas form an international society that supports their needs?

Doctoral students have needs that are not readily addressed by their mentors (supervisors). What are your needs as a doctoral student in your country and would the creation of an international...

05 May 2013 6,658 4 View

Neuroleptics such as thioridazine inhibit efflux pumps of mdr cancer cells. Any member of ResearchGate interested in collaborations?

We have found that phenothiazines inhibit ABC transporters by denying hydrolysis of ATP-

01 January 2013 1,439 0 View