Why antibodies targeting co-inhibitory receptors (such as PD-1) block their inhibitory signalling, while anti-CD3 and CD8 antibodies activate T cells?

While learning tumor immunology, I found that antibodies targeting PD-1 and CTLA-4 could block the immunosuppressive effect of these co-inhibitory checkpoints, but antibodies targeting CD3 and...

09 August 2017 3,555 4 View