Jan Zitko

2 Questions 5 Answers 0 Followers

Questions related from Jan Zitko

Any suggestions on minisci alkylation of pyrazine and similar electron-deficient heteroarenes?

In the literature, most of the examples utilized rather small radicals like methyl or stabilized radicals like isopropyl or tert-butyl. Does anyone have practical experience with long chain...

04 June 2015 9,727 0 View

What are the basic possibilities to identify the target of novel compounds with antimycobacterial activity?

I have prepared a series of 30 derivatives of PZA, some of them exerted activity at MIC = 1ug/mL. What would be the most simple way to attempt to identify the possible subcellular target of these...

13 December 2012 4,911 0 View