How to improve the PLGA nanoparticle encapsulation efficiency of hydrophilic drugs in W/O/W method?

I have been trying to encapsulate VEGF (a kind of protein) using PLGA w/o/w. The EE%, that I determined, was quite low: 10%. Here is the protocol I used: 1. 100 ug VEGF was reconstituted in 1ml DI...

09 September 2018 374 6 View