Hozeifa Mohamed Hassan

5 Questions 16 Answers 0 Followers

Questions related from Hozeifa Mohamed Hassan

CYP2E1 agonist and antagonist?

Beside using the knockout models, I need the most commonly used CYP2E1 agonist and antagonist that used for mimic and block CYP2E1 activity, respectively, especially in rat models. Suggestions...

12 June 2016 6,262 4 View

What are all the possible pathways that could participate in serum TBA elevation which associated with drug-induced hepatotoxicity ?

considering the case of both cholestasis and hepatocyte injury

13 September 2015 8,734 3 View

Is a reduction in biomarkers for drug-induced hepatotoxicity, is it logical ?

Is it possible that, the blood biomarkers for hepatotoxicity (ALT, AST and ALP) could be severely decreased, compared to the normal control, in animal model of hepatotoxicity, after treatment...

15 January 2015 7,159 7 View

What lactate dehydrogenase (LDH) levels should I use for cytotoxicity assay?

the LDH level started to increase with increased drug concentrations, but the higher concentrations gave lower LDH levels compared to the smaller ones. Is it because the higher conc. resulted in...

15 January 2015 9,301 11 View

What is the major criterion in selecting male rats over female ones in hepatotoxicity studies

I would like to verify the choice of male Wistar Albino rats over female in in vivo hepatotoxicity experiments, any justification?

19 February 2014 8,546 2 View