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Questions related from Florian L Muller
I understand that short term fasting in mice and men leads to a decrease in both glucose and lactate levels, with lactate being actively taken up by the liver for gluconeogenesis. I was wondering...
23 April 2017 9,212 1 View
TMZ is FDA approved for GBM in humans but its overall effectiveness is limited. In intracranial mouse xenografts of run-of-the mill GBM cell lines like U87, how well does TMZ perform? I.e. is it...
17 February 2017 1,044 5 View
Cyclophosphamide is supposed to be activated by Cytochrome P450. I've treated Huh7 and PLC liver cancer cell lines with Cytochrome P450, but there is no sensitivity whatsoever, even at 500uM....
27 January 2017 7,296 5 View
I prepared a 50 mM phosphate buffer in H2O and pH'ed it to 7. I lyophilized it and dissolve it in D2O? What is the pD? And what would be the pT (I would like a tritium water solution, ultimately).
03 August 2016 1,315 3 View
I am synthesizing an azide substituted phosphonate and I am unsure whether I have the right product. Starting with a phosphonate (PO3C-R) with a resonance of 10 ppm in the 31P spectrum, what...
03 July 2015 8,544 5 View
I have xenografted human tumor lysates that I am running western blots on. I need to determine the extent of mouse cell contamination in these lysates (I don't have slides for the tumors). I am...
17 June 2013 3,719 7 View
I am wondering whether there are differences in IC50 between mouse, rat and humans for myxothiazol when assayed as purified Complex III activity. I.e. does myxothiazol work unexpectedly become...
10 April 2013 3,475 1 View
