Can anyone figure out how a molecule may activate p53 (upregulation, p53, PUMA, p21) and at the same time promote its ubiquitination?

We are perfoming ubiqitination assays to demonstrate p53 deubiquitination underlying p53 activation, but we found an increase of p53 ubiquitination. Is there any molecular mechanism explaining...

01 March 2013 4,665 3 View