David Arndt

3 Questions 5 Answers 0 Followers

Questions related from David Arndt

Is there a good assay out there to gather quantitative Pharmacokinetic (PK) curve data via saliva samples, not plasma samples in humans?

We would like to collect plasma or oral samples to monitor amphetamine levels after a single dose. We need a quantitative measure. We would highly prefer oral samples over plasma samples. We do...

10 May 2017 6,000 3 View

Has anyone intravenously injected Trichostatin A (TsA) into a rat with saline and 10% DMSO solution serving as vehicle? Any pH issues to be aware of?

We are planning on injecting Trichostatin A intravenously into a rat for a maximum of 20 daily injections. Just wondering if injecting this HDAC inhibitor has any unwanted side effects or pH...

07 October 2015 6,181 2 View

Has anyone investigated fluoxetine in rats and observed severe and significant weight loss and increased immobility in fluoxetine-treated rats?

Rats were administered 'subchronic' fluoxetine at 10 and 20 mg/kg, i.p. 3 times in a 24-hr period before forced swim test exposure. Fluoxetine rats exhibited significant weight loss and emaciation...

03 March 2015 3,576 14 View