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Yalkowsky's GSE is popular and elegant. However, it does not work very well for all solid quaternary ammonium drugs and many zwitterionic drugs. It's thermodynamic basis assumes a CONSTANT...
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Dear Colleagues, I am starting to write a book, "Intrinsic Solubility Data for Pharmaceutical Research." I have studied 1325 publications and have compiled 6352 entries of intrinsic solubility....
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If you have a way to predict the solubility of druglike molecules, you may wish to join the new Solubility Challenge competition: Llinas A, Avdeef A. Solubility Challenge Revisited after Ten...
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