Alagu Sankareswaran

4 Questions 5 Answers 0 Followers

Questions related from Alagu Sankareswaran

When to use inverse rank based normalization for phenotypes in genetic studies?

One of the assumptions in linear regression is that the data should be normally distributed. My data is skewed. I tried log, square root, and several other transformations which I could find still...

31 May 2021 2,414 7 View

If you are not able to detect gender from array data using Xchromosome, what does it mean? Or should we subset the data to detect?

I was trying to match the true gender and gender detected from the X-chromosome data from the Illumina bead chip array. However for many of the samples plink is not able to detect gender,...

31 May 2021 7,588 1 View

How to identify covariates statistically for a genetic association studies?

The genetic association studies need to be adjusted for the covariates such as Age, Gender etc. Is there a statistical way to figure out that? And is it required that all these covariates should...

13 January 2021 511 3 View

How to get TOPMED reference panel ( or south asian specific) for the imputation in Michigan Imputation Server?

Hi All, I am staring into imputation of variants for the genome wide scanning array in past weeks. Though I am able to do imputation using 1000GP3 panel using Impute2 for my dataset, I...

22 August 2020 2,874 1 View