Ahmed H Abdelazeem

3 Questions 3 Answers 0 Followers

Questions related from Ahmed H Abdelazeem

Why do some chemists prefer to perform N-formylation for the free amine before coupling reactions rather than reacting the free amine directly?

Recently, I've seen in a patent a simple N-alkylation reaction of 2-aminobenzothiazole with ethyl bromoacetate. The inventors have carried out N-formylation reaction first followed by coupling...

26 March 2015 6,816 7 View

What are the best reaction conditions for the conversion of thiol (SH) group on a heterocycle ring into hydrazide?

I've used excess hydrazine hydrate in ethanol with reflux for more than two days. The reaction is still incomplete and there is a lot of the starting thiol material. Any suggestions?

16 February 2014 3,741 11 View

Cyanogen bromide (BrCN) handling and safety?

It is the first time that I will use BrCN reagent to form a triazole-2-amino ring. I'm worried about its toxicity and dealing with it. Is there any experience or advice regarding this reagent?...

03 May 2013 6,720 6 View