Dear Sir..try to investigate about aspirin effects on gastric pH, these bacteria able to produce urease enzyme to change pH in order to survive in such harsh condition..search about this fact..!
Yes, to lower the risk for Aspirin induced lesions in the gastric mucosa, included and PUD, but with wich mechanism in correlation with H. pylori infection ...
NSIAD drugs are said to cause PUD, and H.pylori is and organism that is also inplicated in PUD. Starting an Asprin dose in a patient with a H. pylori infection may have a synergistic effect on the patient to develop PUD. Some studies have shown that the errudcation of H.Pylori reduces the chance of developing PUD in patients that a starting on NSIAD therapy.
Persons infected with cagA+tox +Helicobacter pylori strains develop enhanced mucosal inflammation, which may lead to heightened gastric acid secretion with development of gastric metaplasia, colonization by H pylori in the duodenum, and subsequent duodenal ulcer formation.
read more about the pathogenesis on the sites below;
NSAIDs interfere with mucosal defense via direct toxic effects in addition to cyclooxygenase inhibition and subsequent depletion of endogenous prostaglandins