Cytomegalovirus (CMV) is the most common cause of congenital infection.1 Moreover, congenital CMV is the most frequently identified viral cause of mental retardation and is the leading nongenetic cause of neurosensory hearing loss.2,3 In developed countries, congenital CMV infection occurs in 0.3% to 2.4% of all live births.4 Infection in the newborn can be acquired through close contact (via contaminated blood, urine, and secretions), vertically through transplacental transmission, and postnatally through breast milk.1 Most symptomatic neonatal CMV infections occur when a woman is newly infected just prior to or during pregnancy.5