Why serine amino acid is behaving like a positive entity in protein electropotential surface?

10 October 2017 1 8K Report

I have serine aa in the core of protein behaving as a positive entity which i inferred from electropotential surface. as it contain OH negative its should behave as negative entity. I am not able to understand the reason behind this behavior.

Khaleel A Abu-Sbeih

The hydrogen atom in serine's OH group has a partial acidic character, i.e. it is behaving as a proton. Indeed, in serine proteases OH loses a proton and the oxygen acts as a nucleophile.

Badges
Science topic

More Aashish Bhatt's questions See All

How to read gaussian fchk file?

I have run the required calculation for the force constant value in Gaussian successfully and have converted the file.chk file into fchk via formchk. So is there any software which can give...

03 April 2018 699 0 View

During simulation of glucose O5 atom and anomeric OH group are getting attached together.what could be possible reason?how important is charge?

I am facing a problem in (0GA+ROH) GLYCAM carbohydrate parameter while doing force field preparation for glucose molecule in AMBER. I have used Gaussian optimized structure and calculated the MK...

10 November 2017 3,045 0 View

How can calculate resp charge?

I want to know how calculate the resp charge. I have followed the tutorial for understanding of resp charges in amber 16. For calculating the charge i have used only "linker part"...

10 November 2017 4,040 1 View

How can i plot graph in xmgrace?

I have two different set of graph one set is starting from 0-200 and one set is 0-200 on x-axis. how can i merge both sets in xmgrace so that the total graph should be 0-400. means the x axis has...

10 November 2017 1,664 1 View

How can set a parameter for Ag+ ions in AMBER16?

31 December 2016 7,626 4 View

What is the meaning of EPW in water box ?

When I solvate the protein in AMBER16. EPW H2O shown in (AMBER output file) solvated PDB file.I don't understand what is the meaning of EPW. I have attached screenshot. kindly let me know.

31 December 2016 5,528 0 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

What solvent can I used for Paal Knorr reaction between 6-amino hexanoic acid and 2.5 hexanedione?

I am try to make the Paal Knorr reaction between 2.5 hexnedione and 6-amino hexanoic acid, my problem is type of solvent to use, because 6-hexaminohexanoic acid is soluble in water but I am not...

02 March 2021 4,443 2 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

Does any one can help me choose a reasonable basis set for intermediate metal ions interactions with guanine (i.e Fe2+, Mn2+, Cu2+ and exc.)?

Hello every body Does any one has any idea to help me choose a reasonable basis set for intermediate metal ions (i.e Fe2+, Mn2+, Cu2+ and exc.) interactions with guanine or other DNA organic...

01 March 2021 6,187 2 View

How to remove DCU and HOBT from my reaction?

I am doing a acid and a chiral amino alcohol reaction using DCC and HOBT in DCM or THF? Can anyone suggest me how to remove DCU and HOBT from a reaction mixture??

28 February 2021 2,153 1 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View

Why does intensity drops as concentration increases?

Is there any reason for decrease in fluorescence emission intensity of HSA,BSA when increase the concentration ?

28 February 2021 3,653 4 View

POlymer+DMSO solution and moisture??

What could be the reason of moisture at the sides of Vial when I am preparing my polmyer+DMSO solution for membrane fabrication? What etiquettes I am possibly missing here?

28 February 2021 6,516 5 View

What is the most common number of epitopes in an multi-epitope Vaccine?

hi everyone, I'm interested in the field of vaccine design specifically multi-epitope cancer vaccines , I want to know if there is a minimum and maximum number of epitopes we could use in a...

27 February 2021 3,882 3 View