Hi guys,
I need some advice over here.
Im trying to do a liposomal encapsulation via microfluidics of a natural extract diluted in etanol, it is rich in polyphenols. Im using Oleic Acid + Cholesterol + tween 20 for the lipid layer. During the process in getting a precipitate and very few microcapsules.
Use Licithin as the lipid component not oleic acid. Phospholipids are the main components of liposomes.
Você pode tentar também o uso de alkylpolyglucosídeos + phosphatidyl coline, pode ser uma boa opção.
Based on our previous experience, faty acid is not suitable for this process. You can use phospholipid instead of oleaic acid, which would be preferable if you avoid Tween/Span.
https://pubs.acs.org/doi/10.1021/acsabm.1c00563
https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc04491a
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