The main reason is structure of HDL, HDL has two-three LTPs particles which break due to effect of anti-cholesterol agents, but in LDL cholesterol no shuttle particles form due to anti-cholesterol agent. Second LDL contains 1.75%- 2.5% cholesterol in its structure per molecule in additoon to hydrocarbaons and triglycerides in floating stage.
Am I right that HDL contains much more body cholesterol than LDL and because of this its concentration decreases faster? So, can say that novel compounds with such effect is promising for further research?
Murine species are "HDL animal" and not "LDL animal" as human. The answer is in the several differences in lipid metabolism among these animals: CEPT absent in murine; apoB48 secreted in both intestine and liver in murine, etc.
Perhaps it may be of interest to have a look to:
Bravo E, Cantafora A. Liver metabolism of cholesterol taken up from lipoproteins in Wistar rats. An in vivo study comparison between rat and human lipoproteins. Comparative Biochemistry and Physiology 1992; 101B, 637-643.;
Cantafora A, Bravo E, Yan CC. Characterization of lipoprotein fractions isolated from plasma of male Wistar rats by gradient ultracentrifugation. PSEBM 1993; 204, 90-96.
Bravo E, Cantafora A, Calcabrini A, Ortu G. Why prefer the Golden Syrian hamster (Mesocricetus auratus) to the Wistar rat in experimental studies on plasma lipoprotein metabolism? Comparative Biochemistry and Physiology1994; 107B, 347-355.