Which types of IS standards can one use for the analysis of Omeprazole, Pyrimethnamine, Clotrimazole, and Lumefantrine?
Head-to-head studies
Dear Sahar
There is some of the commmon things for selection of IS
1) PKa and Log P of IS is as similar as with Drug Molecule.
2) Structure similarity (Whole Structure/Base Structure) of IS with Drug molecule
3) Saperation of IS and Drug molecule is possible with same mobile phase.
4) Difference between RT is minimum 2 minute between IS and Drug molecule.
So accordingly you have to select your IS as per the Drugs which you want to analyse.
omeprazole can cause neutropenia: I do not know if this is aalso true for other meds
Dear Samir, thanks for the hints. They are really helpful. I'll look att these characteristics and compare them with drugs I want to analyze.
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