What type of screening you need to do? What is the source material for your extracts?
You can make two runs - one using standard C18 column in reversed phases using gradient program H2O-acetonitrile and alternative one using HILIC mode - check the litarature for examples of standard conditions.
I agree with Ana. Your selection depends on both your compounds of interest and your sample matrix. Remember, there is no universal detector (it's just sales BS)!