Which API should be chosen for formulation development of Sotorasib tablets- Racemic mixture (mixture of enantiomer) or single isomer? Does therapeutic efficacy depend on enantiomeric form of sotorasib?
Sotorasib can exist in two atropisomeric forms and one is more active than the other. There is no inactive form and is used as a racemic mixture. Please see the article in C&EN of April 3, 2019, Volume 97, Issue 14.