Although all people living with diabetes are at risk of developing diabetic retinopathy, the pattern of progression and the response to treatment shows variation. Reliable biomarkers that can help to predict the trajectory may be very useful in clinical practice.
According to my experience the progression of diabetic retinopathy is not a linear progressive disease - at least under the circumstances of medical intervention. My expericence is, that you see many patients who had unsufficient careobsdervation for a long time who are at a critical situation (the crisis). After intensive care and treatment, the majority of these patients recover to an unespected morphologically abnd functionally stable situation.
Thank you Heinrich for the response. From this explanation, it is likely that there is no reliable biomarker for progression of DR?
In additon, I think in early DR the number of microaneurysms in fluo angiography is probably the best parameter. Presently, the deep learning projects are on a wrong track: indirect signs of macular edema like hemorrhages and hard exsudates are not sensitive enought!
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