Overall, It could be accessed a good findings by using the two new analytical techniques i.e. D-SIMS and ICP-MS using a very low volume of analyte and a certain amounts of the specific solvents. Of course, It should be considered the budget issue. Take a look to the following links.

https://www.surfacesciencewestern.com/analytical-services/dynamic-secondary-ion-mass-spectrometry-d-sims/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719745/

Regards

For the best results, use compatible vial inserts (that is what they were developed for). Contact your local chromatography supplier or instrument manufacturer for recommendations.

The volume of sample that can be analyzed in a standard GC vial (1.5 ml) depends on the type of injector and the injection technique being used.

For a standard split/splitless injector, the recommended volume of sample is usually in the range of 0.1-2.0 µL. However, the actual volume of sample that can be injected without overloading the column depends on the properties of the sample, such as its boiling point and concentration.

Assuming you are using a 1.0 µL syringe, you can inject up to 1.0 µL of sample into a 1.5 ml GC vial. This volume allows for some headspace above the sample, which can help to prevent the sample from contacting the needle during injection.

It is important to note that injecting too much sample can lead to overloading the column, resulting in poor peak shapes, broad peaks, and/or ghost peaks. Therefore, it is important to optimize the sample volume to obtain the best analytical results.

Noel W Davies Mohammed Almajidi William Letter Hamid Reza Farhang Thank you very much for your valuable responses.