I am designing an exercise intervention and this outcome will help to estimate the power needed for significance.
I imagine that that The change will be as with a "normal" subject.
There appears to be limited research in this area. However, you could expect to find an effect size roughly equal to 0.336 based on Savucu et al.
https://pdfs.semanticscholar.org/bc9e/d802ec7b54cf2ccb255b64a7f5f00f31db46.pdf
A previous review from 2010 may be able to give you a little more guidance. But this looks like an area that could benefit greatly from additional research.
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013297/
Good Luck!
Thank you
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