Zinc Sulphate and Vitamin C are supplements to boost the immunity. Zinc and Ascorbic acid plays a vital role in effectiveness of reticulo endothelial system. Hydroxychloroquine ease out the air-way obstruction. Evaluate the ECG especially RT before prescribing. Hydroxychloroquine is not for prophylactic use.

Hi

Please check the following work. It describes the matters in details. I believe it will help you.

https://clinicaltrials.gov/ct2/show/NCT04335084

Regards

Very good question. It is not only to boost the immunity. Zinc is crucial in many signaling pathways. To answer the question we need additional information from in vitro studies> In exemple, I work on a HCQ-modified molecule with a Co and we should know more soon> I will post the results when data are concrete.

Thank you Packiaraj for your valuable comments. I appreciate the scientific worry on hydrochloroquine however we used it for decades to treat malaria.

Thanks md sazal for the reference to an ongoing clinical trial at least I can follow up the trial but it was address my question.

Thanks vassilis I will appreciate the outcome of your studies.

Dear Abubakar,

Recent studies indicate that hydrochloroquin given alone has more harm than benefits in Covid-19 patients.

Vitamin C is a critical factor in membrane repair process of cells, including airway and gut epithelia.

Zinc: I have done some research with zinc about 10 years ago. My results showed that zinc is an effective blocker of a large conductance calcium-activated chloride current extensively expressed airway and gut secretory epithelia, as well as blood vessels-Cells that are primarily effected by the coronavirus that causes Covid-19. I think zinc block of this channel may benefit in Covid-19 by reducing chloride secretion, subsequently resulting in reduction mucus output that can block the airways and lungs.

For further details and references, please see my publication listed below. Unfortunately in a corpoarte world, my study received very little attention and I received no funding to continue my research.

Article Penetratin Peptide Potentiates Endogenous Calcium-Activated ...

Vitamin C and zinc play important roles in nutrition, immune defence and maintenance of health, Note the research below:

Article A Combination of High-Dose Vitamin C plus Zinc for the Common Cold

Article Immune-Enhancing Role of Vitamin C and Zinc and Effect on Cl...

Abubakar Abubakar Panti

Thanks @Refik for your valuable comments. Your paper was very informative. However, the recent evidence on chloroquine may appear premature to some of hs who have used it for decades to treat malaria without much problem. We use the combination in the treatment of COVID-19 in our environment and more than fifty percent of our patients have been discharged after becoming Negative. Perhaps genetics and environmental factors are at play.

@ Dario thank you for the link to the interesting article on CQ and zinc. It was very informative and useful.

@ luay A. Thanks alot for the links to those interesting articles on Vit C and Zinc they were very useful.

@ Dario thank you sir.

It is not only to boost the immunity. Zinc is crucial in many signaling pathways.

@ Dinka thank you for the valuable comments

Briefly,Zinc has penetrating ability which boost anti micro activity of chloroquine, it also helps immunity maintenance , VitaminC, also helps a lot in boosting patient's immunity which is one of special weapon in combating COVID-19

@ Francis thank you for your valuable comments.

Zink has been shown to have important role in immune boosting. Importantly, Zink has an effective antiviral response. It was further shown in vitro that zinc inhibited coronavirus RdRp activity and that zinc ionophores blocked coronavirus replication. refer :https://doi.org/10.1016/j.mehy.2020.109815

Thank you @ Getandale for your valuable comments and link. It was very useful and informative.

Vitamin C acts an an antioxidant:

Inhibitory Effect of Vitamins C and E on the Oxygen Free Radical Production in Human Polymorphonuclear Leucocytes:

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2362.1994.tb01091.x?sid=nlm%3Apubmed

Zinc acts as an antiviral, and once inside the cell is thought to neutralize the virus. Chloroquine softens the cell membrane and acts as a zinc ionophore, binding to zinc ions and carrying them into the cell where it then stops viral replication via RNA polymerase.

Below are a few articles that may give more understanding to this. The last report is regarding HIV and how zinc added to therapy improved outcomes greatly with suppression of the opportunistic organism, pneumocystis carinii, particularly noted.

There are also some excellent videos regarding zinc and hydroxychloroquine on a medical university teaching website that is free on covid-19, and taught by a molecular biologist and pulmonary intensivist at medcram.com. #34 is real good one.

https://youtu.be/U7F1cnWup9M

Chloroquine Is a Zinc Ionophore:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184484/

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitroand Zinc Ionophores Block the Replication of These Viruses in Cell Culture:

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176

Virucidal Activities of Zinc-Finger Antiviral Proteins and Zinc-Binding Domains for Virus Entry, DNA/RNA Replication and Spread:

http://edelweisspublications.com/articles/48/640/virucidal-activities-zinc-finger-antiviral-proteins-zinc-binding-domains?fbclid=IwAR0GoL1NycSx6LLccFyWgIN8_tzKikkSf13VMFKQfnMq8c7BrJLpnrdyriY

Unrevealing Sequence and Structural Features of Novel Coronavirus Using in silicoApproaches:

The Main Protease as Molecular Target:

https://pubmed.ncbi.nlm.nih.gov/32210741/?from_term=zinc+sars+cov+2&from_pos=3

Therapeutic Application of Zinc in Human Immunodeficiency Virus against Opportunistic Infections:

https://academic.oup.com/jn/article/130/5/1424S/4686403

Hope this helps.

Thanks alot @Suzanne Adam's for your comments and congratulations. The numerous article links were very informative and useful.

Focalizándome en el Covid19: La Vit. C y el Zn, son un excelente dúo como antioxidantes y potenciadores del sistema inmunológico. En lo referente a la Azitromicina, sin lugar dudas es el antibiótico más eficaz para diferentes cuadros infecciosos, incluyendo afecciones respiratorias. En la fase inicial (sintomática) del Covid19, es probable que trabajen bien la combinación de los 3, reemplazando la Hidroxicloroquina por el Ibuprofeno (este AINE, es eficaz en la terapia del Covid19, que prescribe internacionalmente la prestigiosa la Dra. Maria Eugenia Barrientos).

Thank you @Luis I tried to translate your comment to English but was not possible. I'll keep on trying. Thanks for your valuable comments.

Thank you Luis I was able to translate your comments to English. Thanks for your valuable comments

Focusing on the Covid19: The Vit. C and Zn are an excellent duo as antioxidants and immune system boosters. Regarding Azithromycin, it is undoubtedly the most effective antibiotic for different infectious conditions, including respiratory conditions. In the initial (symptomatic) phase of Covid19, the combination of all 3 is likely to work well, replacing Hydroxychloroquine with Ibuprofen (this NSAID is effective in the therapy of Covid19, which is internationally prescribed by the prestigious Dr. Maria Eugenia Barrientos

Addition of Zinc sulfate and Vitamin C along with Hydrochloroquin is a very wise step taken for Covid-19 patients treatment. Zinc sulfate important for nerve function to revive the sense of taste & smell which is lost in Covid-19 patients. Vitamin C as an antioxidant is beneficial as a scavenger of free radicals and thus would be effective in preventing the organ damage from free radicals.

Thanks @ farida for your valuable comments. It is interesting to note that zink reverses the loss of taste.

Some drugs (like hydrochloroquine) have capabilities to bind with metals phenomenon called as Metal-ionophores. Zinc is given to patients because it alleviates respiratory tract infections as reduce viral activities and also contributes in an immunity enhancement. Likewise Vitamin C is given to patients to boost their immunity.

Thanks Santa Arshad for your valuable comments.

Good research is adding other antioxidants to increase immunity and it is titled:

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus.

Article Nutraceuticals have potential for boosting the type 1 interf...

Abubakar Abubakar Panti

Thanks @ luay for your valuable comments and contribution.

Thanns @Subrot Sarma for your valuable contributions.

Follow-up study on HCQ, we have produced a New Fluo-labelled Hydroxychloroquine drug. Very good for in vitro studies +/- Zn and more.

Additional info, please contact me or [email protected]

Thanks @ Vassilis Doucas thanks for your input. This is very intresting I'll private chat you on mail for details.