The study, published in the Annals of Internal Medicine and led by researchers from the University of Oxford, involved 8.26 million adults, 4,053 of them diagnosed as having Down syndrome. The team analyzed information from a primary care database to determine if the abnormal immune responses, congenital heart disease, and lung abnormalities common in people who have the syndrome could be risk factors for severe COVID-19 illness. https://www.cidrap.umn.edu/news-perspective/2020/10/down-syndrome-tied-10-times-risk-covid-19-death
So, what is the relationship of COVID with Down syndrome? Are people with Down among the groups at high risk of developing severe symptoms and death?
All comments and contributions are welcome.
Dear Dr. Hassan Izzeddin Sarsak
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These links may provide useful insights:
Down’s syndrome and COVID-19: risk or protection factor against infection? A molecular and genetic approach
Preprint Down’s syndrome and COVID-19: risk or protection factor agai...
Preprint Down’s syndrome and COVID-19: risk or protection factor agai...
How COVID-19 affects people with Down Syndrome
https://www.news-medical.net/news/20200603/How-COVID-19-affects-people-with-Down-Syndrome.aspx
The genetic susceptibility of people with Down's syndrome to COVID-19
https://medicalxpress.com/news/2021-02-genetic-susceptibility-people-syndrome-covid-.html
Adults with Down syndrome more likely to die from COVID-19 than general population
https://www.news-medical.net/news/20210222/Adults-with-Down-syndrome-more-likely-to-die-from-COVID-19-than-general-population.aspx
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Dear Dr. Terri Purvis
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Manal Hadi Kanaan
Please have a look at this link.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00049-3/fulltext
Thanks!
Manal Hadi Kanaan
Please also see the links below.
https://www.sciencemag.org/news/2020/12/covid-19-10-times-deadlier-people-down-syndrome-raising-calls-early-vaccination
https://www.sciencedaily.com/releases/2021/02/210208100533.htm
Thanks!
Dear Dr. Kanaan!
I would say yes, based on the findings, there is a risk of getting seriously ill with COVID-19 for people with Down-Syndrome:
1) Emami, A., Javanmardi, F., Akbari, A. et al. COVID-19 in patients with Down syndrome. Neurol Sci (2021). https://doi.org/10.1007/s10072-021-05091-8 Open access: Article COVID-19 in patients with Down syndrome
2) Illouz, T., Biragyn, A., Frenkel-Morgenstern, M. et al. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromol Med (2021). https://doi.org/10.1007/s12017-021-08651-5 Open access:
https://link.springer.com/article/10.1007%2Fs12017-021-08651-5
3) A case-study: Emanuele Rocco Villani et al. (2020).Clinical characteristics of individuals with Down syndrome deceased with CoVID‐19 in Italy—A case series American Journal of Medical Genetics, Volume 182, Issue 12, December 2020, Open access:Article Clinical characteristics of individuals with Down syndrome d...
Yours sincerely, Bulcsu Szekely
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De Toma I, Dierssen M. Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19. Sci Rep 2021;11(1):1930. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820501/pdf/41598_2021_Article_81451.pdf
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Recent research, published October 2020, indicates that people with Down Syndrome are at higher risk of severe outcomes from COVID-19. This research has been published in the British Medical Journal and Annals of Internal Medicine and found increased risk of hospitalisation and serious illness in adults ( aged 18 and above) with Down syndrome. There were similar findings in a study published in Genetics in Medicine .The increased risk is age related , and mainly relates to older adults and those with other medical conditions that also increase the risk from COVID-19
please check this link . https://www.dsmig.org.uk/covid-19-and-down-syndrome/
"Patients with DS are among the high-risk populations with respect to severe COVID-19 and should receive the vaccine as soon as possible. Furthermore, they should receive more intensive care if they get hospitalized with the illness."
- Emami A, Javanmardi F, Akbari A, Asadi-Pooya AA. COVID-19 in patients with Down syndrome. Neurol Sci. 2021 Feb 1:1–4.
Article COVID-19 in patients with Down syndrome
Also, I recommend you a recently published article by Illouz et al.
Article Specific Susceptibility to COVID-19 in Adults with Down Syndrome
Dear Dr. Aqeel yousif Alshukri Thank you so much, really thanks. My sincere gratitude, Doctor.
Dear Dr. Mohammad-Salar Hosseini Thank you so much, really thanks. My sincere gratitude, Doctor.
Thanks for the question on Down Syndrome and the links as well
Dear Dr. Samuel Oluyomi Ayodele Thank you so much, really thanks. My sincere gratitude, Doctor.
Please see the following article
Preprint Down’s syndrome and COVID-19: risk or protection factor agai...
Dear Dr. Lamia Mustafa Al-Naama Thank you so much, really thanks. My sincere gratitude, Doctor.
DS is also characterized by the coexistence of obesity and cardiovascular and respiratory anomalies, which are risk factors for coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02471-5
How COVID-19 affects people with Down Syndrome. https://www.news-medical.net/amp/news/20200603/How-COVID-19-affects-people-with-Down-Syndrome.aspx
Down syndrome (DS) is the most common genetic cause of learning difficulties and intellectual disabilities. DS patients often present with several congenital defects and chronic diseases, including immunity disorders. Elevated levels of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) have been seen, which appear to vary with age. At birth, patients present with combined immunodeficiency, with frequent infections that decrease with age. Furthermore, high levels of IL-4 and IL-10 with anti-inflammatory properties and low levels of IL-6 and TNF-α are described in children. The immune system is believed to play an essential role in SARS-CoV-2 pathogenesis, and it has been associated with elevated levels of pro-inflammatory cytokines and an exaggerated cytokine release syndrome (CRS) that may eventually trigger a severe situation called cytokine storm. On the other hand, genetic features seem to be involved in the predisposition to illness and its severity. Overexpression of DSCR1 and ZAKI-4 inhibits the translocation of activated T lymphocyte nuclear factor (NF-AT) to the nucleus, a main step in the inflammatory responsiveness. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683327/
COVID-19 is 10 times deadlier for people with Down syndrome, raising calls for early vaccination https://www.sciencemag.org/news/2020/12/covid-19-10-times-deadlier-people-down-syndrome-raising-calls-early-vaccination
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Manal Hadi Kanaan
Adults with Down syndrome more likely to die from COVID-19 than the general population. A new study by an international team of researchers found that adults with Down syndrome are more likely to die from COVID-19 than the general population, supporting the need to prioritize vaccinating people with the genetic disorder
https://www.cidrap.umn.edu/news-perspective/2020/10/down-syndrome-tied-10-times-risk-covid-19-death
Dear Dr. Nirmala S.V.S.G Thank you so much, really thanks. My sincere gratitude, Doctor.
Dear Dr. Umar Ashraf Thank you so much, really thanks. My sincere gratitude, Doctor.
Down syndrome is a genetic condition. It occurs when a child is born with 47 chromosomes instead of the regular 46. The extra chromosome is chromosome 21. The extra chromosome causes delays in brain development and several physical abnormalities. A number of children and adults with Down syndrome will fall into these higher risk groups.
Dear Dr. Prof Dr Suhad Qasim saeed Almousawi Thank you so much, really thanks. My sincere gratitude, Doctor.
Thant is a nice explanation Prof Dr Suhad Qasim saeed Almousawi
Down syndrome increases the risk of lung infection in general, so it increases the risk of infection with Covid 19. Down syndrome is already associated with an increased exposure to many health problems associated with the severity of Covid-19 symptoms — including heart disease, sleep apnea, obesity and diabetes. Many adults with Down syndrome live in nursing homes, where it can be difficult to avoid exposure to germs transmitted by residents and staff. Down syndrome also often affects mental abilities, so it can be difficult for this group to follow preventive measures.
According to the Centers for Disease Control and Prevention (CDC), people with Down syndrome are at an increased risk of severe illness from COVID-19. The CDC recommends that people with Down syndrome receive the COVID-19 vaccine as soon as possible. It is important to consult with a healthcare provider for more information on how to protect yourself or your loved ones from COVID-19.
According to the current web page context, there have been rare cases of blood clotting after vaccination with certain COVID-19 vaccines. However, it is not confirmed that these cases are caused by the vaccine.
The benefits of vaccination outweigh the risks for most people. The COVID-19 vaccines have been shown to be safe and effective at preventing COVID-19.
If you have questions or concerns about the COVID-19 vaccine, it is important to talk to your doctor or a healthcare professional.