See:

http://www.ncbi.nlm.nih.gov/pubmed/22017878

http://www.ncbi.nlm.nih.gov/pubmed/3915829

The International Toxicity Estimates for Risk (ITER) database offers risk values from various organizations. For example, I have provided a permalink to the RfD and other noncancer risk information for manganese. Also provided as a link is the (U.S.) national Library of Medicine's home page for ITER. Disclaimer: These comments are my own and do not necessarily reflect the views of NLM/NIH.

http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+iter:@term+@DOCNO+iter-7439-96-5

http://toxnet.nlm.nih.gov/newtoxnet/iter.htm

Useful papers thank you Kathrine Springman.

Thank you Dr. Pertti Hakkinen for sending the required links.

The European Food safety Authority (EFSA) recently released an assessment of Ni. Cd, Pb have also been evaluated by EFSA and WHO-JECFA. For micronutrients (e.g. Zn), the Institute of Medicine (IOM) has produced evaluations. For Cr you may have to differentiate between Cr III (a micronutrient) and Cr VI.

Thank you Dr. Benoit Schilter. 

Copper: WHO has published 1997 an AROI (acceptable range of oral intake, see EHC 200) for tis micronutient, whose upper limit may serve as a RfD for adults, but not necessarily for newborn and babies. Its upper limit in drinking-water is 2 mg/L due to inacceptable taste and acute effects on the digestive tract

Manganese: If looking for a toxicologically safe RfD you have to differentiate between soluble Mn2+ and Mn-oxides. The latter are insoluble at physiological pHs down to pH 2 and hence much less toxic than Mn2+ - salts. I propose a RfD for Mn2+, applicable on babies and young children, in my publication "Drinking-water toxicology in its regulatory framework" cited on RG (please ask for a personal copy).

Chromium: There is ongoing debate on the carcinoegenic potential of oral Cr(VI) with proposed maximal values for drinking-water in the lower µg/L - range and below, referring theoretically to an additional lifetime risk of 10E-6 for liver cancer

the oral referencing dose for Cr, Ni, Cu, As, Cd, Pb and Hg is 0.003, 0.02, 0.04, 0.0003, 0.001, 0.004 and 0.0005 mg/kg respectively. Thank you

Thank you Ababo...

The oral reference dose for Cu, Cd, Pb is 0.04, 0.001, 0.04 mg/kg respectively. For further details check .

United States Environmental Protection Agency (USEPA),

Guidance for Assessing Chemical Contaminant Data for Use in

Fish Advisories, vol. 2, Risk Assessment and Fish Consumption

Limit, EPA/823/B-97/009,Office of Science and Technology and

Office ofWater,Washington, DC, USA, 3rd edition, 2000.

United States Environmental Protection Agency (USEPA),

“Human health risk assessment, risk-based screening table,

regional screening level (RSL) summary table,” 2015, http://

semspub.epa.gov/work/03/2218434.pdf.

Kindly is there any one who give me the the oral reference dose for elements such as Al and Zn to calculate the THQ in herbal medicinal plants ?

Oral reference dose of Zn is 0.3. For further reading check United States Environmental Protection Agency (USEPA), “Human health risk assessment, risk-based screening table, regional screening level (RSL) summary table,” 2015, http://semspub.epa.gov/work/03/2218434.pdf.

WHO (World Health Organization), “Evaluation of certain food additives and contaminants: seventy-third report of the joint FAO/WHO expert committee on food additives,” WHO Technical Report Series 960, WHO, 2011, http://whqlibdoc.who.int/trs/WHO TRS 960 eng.pdf.

Article Heavy Metal Levels in Muscle Tissues of Solea solea, Mullus ...

Sending RfD values for 10 metals except Co..

Thank you Peter TAIWO Olagbemide and Cengiz korkmaz.

thank everyone for the valuable contributions, i am benefiting.

thank u all

what is the reference dose value of Zn in drinking water?

Peter TAIWO Olagbemide , please kindly send me the USEPA document on reference dose to [email protected] as i am unable to retrieve the document online.

thanks

US EPA (2013): Reference dose (RfD): Description and use in health risk assessments, Background Document 1A, Integrated risk information system (IRIS); United States Environmental Protection Agency: Washington, DC, 15 March 2013; http://wwwepa.gov/iris/rfd.htm.

Hi,

Whether the oral reference dose for Hg and As is 0.0003 mg/kg?

Looking for your suggestions...

According to the USEPA 2000, oral reference doses (mg/kg/day) for several metals are follows. Cr (III)=1.5 , Fe = 0.7, Cu = 0.04, Zn = 0.3, As = 0.014, Cd = 0.001, Pb = 0.004, Ni = 0.91

Hi Nalika R. Dayananda thanks for sharing the oral reference dose values.

What are the oral reference doses (RfD(s)) for

1. Rubidium (Rb)

2. Titanium (Ti)

3. Zirconium (Zr)

4. Thorium (Th)

Ndiye Michael Kebonye

Only RfD value for Zirconium (Zr) is available, which is equal to (8E-5)

Thank you Sherif Elgammal

RfD for Cu= 0.04, Zn= 0.3, Mn= 0.14, Ni= 0.02, Cd= 0.001, Pb= 0.004, Cr= 1.5 Fe= 0.70 mg kg -1 day -1 (US EPA, 2000)

Mohamed N. Monier ..Can you please provide the reference document for the RfD values mentioned. I tried to retrieve but it's not working.

Thanks and regards

https://semspub.epa.gov/work/HQ/400431.pdf

Cd diet mg/Kg 0,001 mg/Kg/day

Cr III mg/Kg 1,5 mg/Kg/day

Cu mg/Kg 0,04 mg/Kg/day

CH3 Hg mg/Kg 0,0001 mg/Kg/day

Mn diet mg/Kg 0,14 mg/Kg/day

Ni refinery dust mg/Kg 0,011 mg/Kg/day

Zn mg/Kg 0,3 mg/Kg/day

Saurabh Shukla

Many thanks