Some options to consider include:

• Lung epithelial cells (e.g. A549, Calu-3) - As SARS-CoV-2 infects the respiratory tract, using lung epithelial cell lines makes sense as they would be physiologically relevant. The virus can directly infect these cells and elicit an inflammatory response.
• Macrophages (e.g. THP-1, U937) - Macrophages play a key role in cytokine release and inflammation during viral infections. THP-1 or U937 human monocytic/macrophage cell lines could be differentiated and infected with SARS-CoV-2.
• Dendritic cells (e.g. monocyte-derived DCs) - Dendritic cells bridge innate and adaptive immunity, detecting pathogens and promoting cytokine/chemokine secretion. Generating monocyte-derived dendritic cells and infecting them with SARS-CoV-2 is an option.
• Endothelial cells (e.g. HUVECs) - The endothelium is affected in COVID-19. HUVECs (human umbilical vein endothelial cells) could be used to see endothelial activation/dysfunction.

Hello Fabiana Barcelos Furtado

You may use human hepatoma 7 cell line (Huh7) for your study as these cells are highly permissive for SARS-COV-2 replication. Many cytokine-related genes, including chemokines, interleukins, tumor necrosis factor, and IFN are upregulated upon viral stimulation in Huh7 cells, suggesting the presence of a cytokine storm. Using this cell line of liver origin would be interesting as the liver has been identified as one of the main target organs in cases of COVID-19.

For more information you may want to refer to the articles attached below.

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1003608/full

Article Highly infectious SARS-CoV pseudotyped virus reveals the cel...

Article The FDA-approved gold drug auranofin inhibits novel coronavi...

https://www.frontiersin.org/articles/10.3389/fmicb.2021.768740/full

Article Impact of COVID-19 on liver

Best.