From the description in this link, it seems like key size of 128 or greater is assumed to be one metric to determine strength of the protocol. It is a symmetric key, block cypher. This two fish algorithm was apparently one of the finalists, but ultimately beaten by AES.

https://choosetoencrypt.com/tech/twofish-encryption/

The above states that one issue with the two-fish algorithm was that it depends on precomputed and key-dependent S boxes. You're precomputing the keystream, which you will be using, as opposed to doing this on the fly. So, this could make the scheme vulnerable, if an attacker can access those precomputed S boxes.

That aside, the link does not claim the algorithm was actually broken.

Two fish is a block cipher (Feistel network) designed by Bruce Schneier and one of the finalists of the AES competition. It uses a block size of 128 bits and variable key length up to 256 bits with 16 rounds. Converting a block cipher into a lightweight algorithm seems not to be a good idea. If you want to use a lightweight block-cipher, then there are many such candidates available. ( see https://csrc.nist.gov/projects/lightweight-cryptography/round-2-candidates). However, if you mandatory required to propose a new algorithm, then it is better to start from scratch after doing a comprehensive related literature review.

hank you so much

Twofish is a symmetric block cipher; a single key is used for encryption and decryption. Twofish has a block size of 128 bits, and accepts a key of any length up to 256 bits. (NIST required the algorithm to accept 128-, 192-, and 256-bit keys.) Twofish is fast on both 32-bit and 8-bit CPUs (smart cards, embedded chips, and the like), and in hardware. And it’s flexible; it can be used in network applications where keys are changed frequently and in applications where there is little or no RAM and ROM available.

Thanks a lot