I am working on developing a segmentation algorithm that can be applied for identifying cancerous regions in CT/MRI-Lung, CT/MRI-brain and CT/MRI-mammography images. I have been trying to evaluate evolutionary algorithm for segmentation that can be applied to all set of images as mentioned above. What I found is while in some cases it gives significantly good results, in others it does not. What is in general a better approach for medical image segmentation :

-> Old School Thresholding approach

-> Machine learning approach (Deep Neural Network, CNN etc)

-> Meta heuristics (Genetic Algorithm, PSO, Simulated Annealing etc) 

or any other methods.... 

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